Genetics

Newer antipsychotics no safer than older ones

21/01/2009 | The risk of sudden cardiac death is as high with newer atypical antipsychotics as it is with older, typical antipsychotics, and their use in some patients should be reduced sharply, says an article and accompanying editorial in The New England Journal of Medicine.


Hypertrophic cardiomyopathy: still a challenge after 50 years

10/10/2008 | Fifty years after the syndrome was first described in detail, hypertrophic cardiomyopathy remains a challenge for cardiologists because of difficulties in predicting those at greatest risk and a lack of specific evidence on treatment. Source: Elliott. P. et al. Heart 2008; 94: 1269-1275.


Risk factors for migraine in Marfan syndrome

03/09/2008 |  Results of a study presented at this year's ESC congress show that 44% of Marfan's patients suffer from migraine.


Common variant in the SLCO1B1 gene linked to statin-induced myopathy

01/08/2008 | A genomewide association study published in the NEJM has revealed a strong association between a common variant in the SLCO1B1 gene with high-dose statin-induced myopathy. Source: The SEARCH Collaborative Group. NEJM 2008; 359: DOI:10.1056/NEJMoao801936.


Exercise ECGs better at detecting cardiac abnormalities in athletes

11/07/2008 | Exercise electrocardiograms may pick up cardiac abnormalities in athletes that are missed by resting, or baseline, ECGs, Italian researchers report. Source: Sofi, F. et al. BMJ 2008;337:a346.


ARBs slow rate of progressive aortic root dilation in Marfan’s syndrome

02/07/2008 | Angiotensin-2-receptor blockers slow the rate of progressive aortic root dilation in patient’s with Marfan’s syndrome, according to the results of a small pilot study. Source: Brooke, B. et al. New Engl J Med 2008; 358: 2787-2795.  


AHA urges ECG before children take drugs for ADHD

09/05/2008 | Children with attention deficit hyperactivity disorder should have an electrocardiogram and a cardiac evaluation before they begin to take drugs for the disorder, the American Heart Association has said in a scientific statement. Source: AHA Scientific Statement Circulation 2008; 117: 2407-2423.


“Aspirin resistance” linked to negative cardiovascular outcome

29/01/2008 | A BMJ study suggests “aspirin resistance” is a true biological entity that increases a patient’s risk of adverse cardiovascular outcome regardless of whether aspirin is used alone or with adjunctive antiplatelet therapy. Source: Krasopoulos, G.BMJ 2008; doi:10.1136/bmj.39430.529549.BC


Abnormal ECGs in athletes: A benign expression of athletic conditioning?

13/01/2008 | An abnormal electrocardiogram in a young, highly trained athlete might be the first expression of underlying cardiomyopathy, and not simply an innocent expression of cardiac remodeling associated with systematic and intensive exercise, a study suggests.Source: Pelliccia, A. et al. New Engl J Med 2008; 358:152-161.


AI system predicts medicine's hidden powers

05/09/2007 | Treatments for new or drug-resistant infectious diseases may already be in our medicine cabinets, say the molecular biologists responsible for developing an artificial-intelligence system that can predict unknown antibiotic properties of existing drugs.


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