Oestradiol extremes increase mortality in men with CHF

Men with chronic heart failure have a significantly increased mortality risk if their oestradiol levels are low or high, a study finds. Men with low oestradiol levels had as much as a 50% lower survival compared with men who had mid-range levels of the hormone, the researchers reported in the latest edition of JAMA. The researchers say that their in insufficient evidence to consider oestradiol supplementation as a treatment for HF, and their results suggest the response may be complex. They divided 501 men with CHF and reduced left ventricular ejection fraction into 5 quintiles depending on the level of oestradiol in their blood. Quintile 3 was considered the reference group....